Compute Iterative Correction.

Compute Iterative Correction (Vanilla Count) on hic maps.

Usage

ICEnorm(hic.cmx, qtlTh.num = 0.15, maxIter.num = 50)

Arguments

hic.cmx

<contactMatrix>: The HiC maps chunk to normalize.

qtlTh.num

<numerical>: The threshold quantile below which the bins will be ignored. (Default 0.15)

maxIter.num

<numerical>: The maximum iteration number.

Value

A normalized contactMatrix

Details

ICEnorm

Examples

data(HiC_Ctrl.cmx_lst)
HiC_Ctrl_ICE.cmx <- ICEnorm(HiC_Ctrl.cmx_lst[['2L_2L']])